TCU hung around within striking distance until the final four minutes but the Horned Frogs' thin bench was too much to overcome against No. 20 West Virginia on Monday night.
The Mountaineers (19-7, 8-5 Big 12) pulled away in the final three minutes to beat TCU 82-66 at WVU Coliseum.
TCU was playing with just seven scholarship players. Shawn Olden was still unavailable after suffering a concussion at Kansas.
The Frogs (17-9, 5-8) are now 0-6 all-time in Morgantown. The Frogs are 2-5 on the road in the Big 12 this season. WVU avenged its first-ever loss to TCU from two weeks ago in Fort Worth. The 16-point loss is the biggest for TCU this season. The Frogs' first five losses in the league were by a combined 19 points.
"I would say they probably wore us down, but, again, they beat us in pretty much every category," TCU coach Jamie Dixon said. "They just turned the tables on the other game, to be honest with you. We could probably switch the box scores."
The last time TCU defeated a ranked team on the road was No. 24 Hawaii on Jan. 19, 1998.
TCU hosts Oklahoma State at 7 p.m. Saturday.
Desmond Bane and Vladimir Brodziansky scored 16 and 15 points to lead the Frogs. James Bolden and Teddy Allen each had 14 points for WVU.
TCU twice closed within five in the second half, but went without a field goal over a crucial four-minute stretch and West Virginia capitalized with a rare strong finish. The Mountaineers outscored the Horned Frogs 15-7 over the final three minutes.
With less-than-stellar games from leading scorer Jevon Carter and shot-blocking specialist Sagaba Konate, West Virginia overcame a sluggish start with sparks from reserves Allen, Bolden and Maciej Bender to move ahead for good late in the first half. West Virginia's 38 bench points were its most in a Big 12 game this season. WVU shot 50.8 percent compared to TCU's 42.8 percent. The Frogs also missed seven free throws.
"We had our opportunities, had our chances," Dixon said. "We came back in the second half, got it to five, even though I didn’t think our offense was very good. We were getting some deflections, we were getting some loose balls, rebounds were coming our way, but, at the end of the day, we just couldn’t sustain good offense with that."
TCU: The Horned Frogs couldn't mirror their offensive performance in an 82-73 win over West Virginia on Jan. 22. TCU is fighting for its first NCAA Tournament bid in 20 years, but it's been that long since the Horned Frogs have beaten a ranked team on the road.
West Virginia: The Mountaineers posted their third win in four games but time is running out in their quest for a first-ever Big 12 regular-season title. The good news is there are still head-to-head matchups ahead with Kansas and first-place Texas Tech, the two teams they need to beat to get there.
TCU goes for a regular-season sweep of Oklahoma State at home on Saturday.
West Virginia plays at No. 13 Kansas on Saturday. The Mountaineers have never won at Allen Fieldhouse, blowing a 14-point lead with 3 minutes left in regulation and losing in overtime 84-80 last season.
This report includes material from The Associated Press.