TCU running back Waymon James is out for the rest of the season after injuring his knee in the fourth quarter at Kansas.
James, who led the Horned Frogs in rushing last season, was their leading rusher through two games with 168 yards. He had 99 yards in TCU's 20-6 win at Kansas.
Television replays showed James clutching a knee after planting it hard in the fourth quarter and being looked at by trainers on the sidelines.
The loss leaves TCU with one experienced running back, Matthew Tucker. The senior has rushed for 2,187 yards and 27 touchdowns in his career, including 100 yards on 19 carries through two games this season.
No. 17 TCU (2-0) hosts Virginia (2-1) at 11 a.m. Saturday at Amon G. Carter Stadium.
Tucker had 702 yards last season, third-best on the team behind James and Ed Wesley. Tucker led the Frogs with 12 touchdowns. He has averaged 5.7 yards per carry in his career.
Wesley led the Frogs in rushing in 2010 but left the program in the spring.
True freshman B.J. Catalon and senior Aundre Dean are likely to step into more prominent roles. Catalon has 61 yards on 15 carries in two games. He also has four receptions for 57 yards. Dean has 29 yards on eight carries and has been used sparingly in his TCU career after transferring from UCLA after his freshman season. Dean had 130 yards on 31 carries in 2011, including 67 yards on 11 carries against Louisiana-Monroe, his most extensive playing time at TCU.
"I trust one guy right now," Patterson said after Wednesday's practice. "The other two will have to play, but right now I trust one. We're down to one guy who has really played, so I'm not sure I can say I have confidence in that."
James led the Frogs with 875 yards last season. As a redshirt freshman, James rushed for 513 yards and five touchdowns in 2010. James averaged 7.2 yards per carry in 2011, scoring six touchdowns while he shared duties with Tucker and Wesley.
James, a junior, would be eligible to apply for a medical redshirt. If approved, he'd still have two seasons of eligibility left.
EA Sports is on the TCU campus this week laser-scanning images of Amon G. Carter Stadium for use in its NCAA '14 game.
Someone bring the coffee and donuts. Fans are encouraged to arrive early at Frog Alley on Saturday for the team's arrival at Amon G. Carter Stadium. The Frog Walk, which was a success in its inaugural run before the Frogs' Sept. 8 opener, will be at 8:30 a.m. before the 11 a.m. start against Virginia.
"I've got to do my job. I may be sharing it with B.J. and Aundre, but I still have my job to do." Running back Matthew Tucker, on losing Waymon James
17Years since Virginia played a game in the state of Texas. The Cavaliers lost 17-16 at Texas in 1995. Their only other trip to the Lone Star State was in 1977, when Heisman-winner Earl Campbell rushed for 156 yards and two touchdowns in the Longhorns' 68-0 win.